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KMID : 0043319980210020153
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Archives of Pharmacal Research
1998 Volume.21 No. 2 p.153 ~ p.156
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Cytotoxic Constituents of Saussurea lappa
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Jung Jee-Hyung
Kim Young-Soo
Lee Chong-Ock
Kang Sam-Sik
Park Jong-Hee
Im Kwang-Sik
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Abstract
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The crude extract of Saussurea lappa displayed significant lethality to brine shrimp larvae. Investigation of the causative components by bioactivity-directed fractionation resulted in the isolation of three -polyene alcohols. Based on various nmr spectral data, these compounds were identified as shikokiols which had been previously isolated from Cirsium nipponicum and/or Centaurea aegyptica. These -polyene alcohols exhibited moderate cytotoxicities against the human tumor cell lines, A549, SK-OV-3, SK-MEL-2, XF498, and HCT15.
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KEYWORD
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Saussurea lappa, Compositae, -polyene alcohol, Cytotoxicity, Shikokiols, Brine shrimp
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